I had been editing a file, saving it, and finding the changes were not being picked up. Looking back, it was obvious; I was using CTRL-S the familiar Linux command, instead of F3 on ISPF.
I fixed this by configuring X3270 (on Linux).
My file /home/colin/.x3270pro now has
...
x3270.keymap: mine
! Definition of the 'mine' keymap
x3270.keymap.mine: #override \
Alt<Key>4: String("\\x00a2")\n\
Ctrl<Key>backslash: String("\\x00a2")\n\
<Key>Escape: Clear()\n\
<Key>End: FieldEnd()\n\
Ctrl<Key>Delete: EraseEOF()\n\
Ctrl<Key>Right: NextWord()\n\
Ctrl<Key>Left: PreviousWord()\n\
Ctrl<Key>Up: Home()\n\
<Key>Control_L: Reset()\n\
<Key>Control_R: Reset()\n\
<Key>Prior: PF(7)\n\
<Key>Next: PF(8)\n\
<Btn3Down>: PA(1)\n\
Ctrl<Key>1: PA(1)\n\
Ctrl<Key>s: MoveCursor(3,15) String("save") Enter()\n\
When I started a new X3270 session, Ctrl -S went to the command line, typed save and pressed enter. Job Done ! The numbers are 0 based, so 3 means line 4 on the screen.
This makes life so much easier!